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Exactly as Anadrol, Dianabol is orally active steroid allowing oral administration as it comes in form of tablets. Dianabol was first approved in 1988. The pharmacokinetic profile is shown in . First passes are about 4 – 5 hours. Second passes are about 1 – 1.5 hours. The longest period for D-Aspartate metabolism is 15-25 hours. The half-life is about 3-7 hours. Most studies have shown that the blood concentration of (A-D) is highest 2-3 hours after oral administration compared with the half-life. A plasma D-aspartate concentration higher than the peak D-Aspartate concentration is likely to cause adverse reactions. Therefore, in this situation it may be advantageous, if one wants to increase the D-aspartate concentration, to immediately administer D-Aspartate in the morning to reduce the risk of D-Aspartate toxicity.D-Aspartate is the precursor of A3, a protein (aspartate) that regulates cell growth, cell division, differentiation, and many other aspects of cell metabolism, signaling, and proliferation. It has a broad spectrum of biological activities. In the brain, SLC6A4 converts glutamate to GABA. In the heart, SLC6A6 converts Ca2+ to aldosterone. In the blood, it is mainly responsible for its anti-arrhythmic effects. It is also responsible for its cardiac vasodilatory effects. It is an anti-diuretic, blood sugar-lowering, and cholesterol-lowering agent. The A3 has a number of metabolic effects and is also needed by certain cells.The A3 synthesis pathway is mediated by SLC6A4. The A3 in turn synthesizes the A2 precursor acetyl-CoA which is converted to A1. The A2 then uses as much as 40% of the energy in order to synthesize the A3. Its conversion is mediated by the P450 family member 3A4. It also has other biological functions, many of which are important for the survival of the organism. It can act as a source of oxygen for tissue (including the brain) during the redox state, it increases the body's production of glucose, enhances the metabolism of fatty acids, and it has a number of other roles. The A3 is a substrate for several enzymes (like methionine synthase, glutamate dehydrogenase and glutathione peroxidase) that are needed for protein synthesis. An example of its roles is the phosphorylation of AMP-Related Article: